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Bromomethane Quickview (CASRN 74-83-9)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Bromomethane

File First On-Line: 01/31/1987; Last Significant Revision: 04/01/1992

Category (section)
Status
Last Revised
Oral RfD Assessment On-line 07/01/1991
Inhalation RfC Assessment On-line 10/01/1992
Carcinogenicity Assessment On-line 08/01/1990
Synonyms
  • 74-83-9
  • Brom-o-gas
  • Bromomethane
  • Dowfume MC-2 Soil Fumigant
  • Dowfume MC-33
  • EDCO
  • Embafume
  • Haltox
  • Kayafume
  • MB
  • Methane, bromo-
  • more...
Bromomethane Source Documents
Revision History
Date Section Description
04/01/1997 III., IV., V. Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information.
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
UF RfD
Epithelial hyperplasia of the forestomach NOAEL : 1.4 mg/kg-day 1000 1.4 x10-3 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Critical Effect
Point of Departure*
UF RfC
Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity LOAEL (HEC): 4.8 x10-1 mg/m3 100 5x10-3 mg/m3

* The Point of Departure listed serves as a basis from which the Inhalation RfC was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • D (Not classifiable as to human carcinogenicity)
  • Weight-of-Evidence Narrative:
    • Inadequate human and animal data: a single mortality study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power. Bromomethane has shown genotoxicity.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

  • Not Assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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