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Di (2-ethylhexyl)phthalate (DEHP) Quickview (CASRN 117-81-7)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

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Status of Data for Di (2-ethylhexyl)phthalate (DEHP)

File First On-Line: 01/31/1987; Last Significant Revision: 09/07/1988

Category (section)
Last Revised
Oral RfD Assessment Yes 01/31/1987
Inhalation RfC Assessment No
Carcinogenicity Assessment Yes 09/07/1988
  • 117-81-7
  • BEHP
  • Bis(2-ethylhexyl)-1,2-benzene-dicarboxylate
  • Bis(2-ethylhexyl)phthalate
  • Bisoflex 81
  • Bisoflex DOP
  • Compound 889
  • DAF 68
  • DEHP
  • Di(2-ethylhexyl)orthophthalate
  • Di(2-ethylhexyl)phthalate
  • more...
Di (2-ethylhexyl)phthalate (DEHP) Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Increased relative liver weight LOAEL : 1.9 x101 mg/kg-day 1000 2 x10-2 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

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Reference Concentration for Chronic Inhalation Exposure (RfC)

Not Assessed under the IRIS Program.

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Carcinogenicity Assessment for Lifetime Exposure
  • Weight-of-Evidence Characterization
    • B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)
  • Weight-of-Evidence Narrative:
    • Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes.
    • This may be a synopsis of the full weight-of-evidence narrative. See IRIS Summary.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
1.4 x10-2 per mg/kg-day Linearized multistage procedure, extra risk
Drinking Water Unit Risks
4x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 3x102 µg/L
E-5 (1 in 100,000) 3x101 µg/L
E-6 (1 in 1,000,000) 3 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Not Assessed under the IRIS Program.

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