Jump to main content.

Biphenyl Quickview (CASRN 92-52-4)

Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of toxicity data by U.S. EPA health scientists from several Program Offices, Regional Offices, and the Office of Research and Development.

Disclaimer: This QuickView represents a snapshot of key information. We suggest that you read the IRIS Summary to put this information into complete context.

For definitions of terms in the IRIS Web site, refer to the IRIS Glossary.

Status of Data for Biphenyl

File First On-Line: 01/31/1987; Last Significant Revision: 08/27/2013

Category (section)
Last Revised
Oral RfD Assessment Yes 08/27/2013
Inhalation RfC Assessment Discussion 08/27/2013
Carcinogenicity Assessment Yes 08/27/2013
  • 92-52-4
  • Bibenzene
  • Biphenyl
  • Biphenyl, 1,1-
  • Diphenyl
  • Lemonene
  • Phenador-X
  • Phenylbenzene
  • PHPH
  • Xenene
Biphenyl Source Documents
Chronic Health Hazard Assessments for Noncarcinogenic Effects

Reference Dose for Chronic Oral Exposure (RfD)

Critical Effect
Point of Departure*
Renal papillary mineralization in male F344 rats BMDL10 (HED99): 13.9 mg/kg-day 30 5 x10-1 mg/kg-day

* The Point of Departure listed serves as a basis from which the Oral RfD was derived. See Discussion of Conversion Factors and Assumptions for more details.

Top of page

Reference Concentration for Chronic Inhalation Exposure (RfC)

Information reviewed but value not estimated. See IRIS Summary.

Top of page

Carcinogenicity Assessment for Lifetime Exposure

Quantitative Estimate of Carcinogenic Risk from Oral Exposure

Oral Slope Factor(s)
Extrapolation Method
8 x10-3 per mg/kg-day Multistage model with linear extrapolation from the POD (LED10).
Drinking Water Unit Risks
2.3x10-7 per µg/L
Risk Level
E-4 (1 in 10,000) 430 µg/L
E-5 (1 in 100,000) 43 µg/L
E-6 (1 in 1,000,000) 4 µg/L

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure

  • Information reviewed but value not estimated. See IRIS Summary.

Top of page

Recent Additions | Advanced Search | IRIS Home | Environmental Assessment | Research

Local Navigation

Jump to main content.