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Citation
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HERO ID
7520
Reference Type
Journal Article
Title
Short-term test for the induction of lung tumor in mouse by chloroprene
Author(s)
Dong, QA; Xiao, BL; Hu, YH; Li, SQ
Year
1989
Is Peer Reviewed?
Yes
Journal
Biomedical and Environmental Sciences
ISSN:
0895-3988
EISSN:
2214-0190
Volume
2
Issue
2
Page Numbers
150-153
Language
English
PMID
2590500
Abstract
In a previous study by the authors, positive results from both a case-control study and a cohort study were reported. In the present study a short-term test for the induction of mouse lung tumor by chloroprene was conducted to confirm whether chloroprene monomer itself can induce tumors. Kunming albino mice weaned at 2 weeks were subjected to inhaling 0, 2.9 +/- 0.3, 19.2 +/- 1.9, and 189.0 +/- 13.3 mg/m3 chloroprene (GC purity, 99.8%) 4 h daily (except Sunday) for 7 months. All survivors were killed at the end of the 8th month or when moribund. No lung tumors were found before the 6th month. Thus, survivors at the 6th month were counted as effective animals. Most lung tumors observed were papilloadenomas (50/57), and a few were adenomas (7/57). The tumor incidence in the 2.9 mg/m3 group was 8.1% in comparison to 1.3% in the control group, with the significance level at P less than 0.05. The higher the concentration, the higher the incidence. Examination of the multiplicity of tumor induction also demonstrated a dose-response relationship, and the number of tumors per mouse in the 189 mg/m3 group was significant at P less than 0.01.
Keywords
Animals; Butadienes/toxicity; Carcinogenicity Tests; Chloroprene/toxicity; Lung Neoplasms/chemically induced; Time Factors; 126-99-8
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
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