US EPA

625433 

Technical Report 

EPA Report 

Toxicological review of Chloroprene (CASRN 126-99-8) in support of summary information on the Integrated Risk Information System (IRIS) 

U.S. Environmental Protection Agency :: U.S. EPA 

2010 

Yes 

U.S. Environmental Protection Agency 

Washington, DC 

EPA/635/R-09/010F 

303 

English 

https://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=P1008LW6.txt 

This document presents background information and justification for the Integrated Risk Information System (IRIS) Summary of the hazard and dose-response assessment of chloroprene. IRIS summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal of entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). Reference values are generally derived for chronic exposures (up to a lifetime), but may also be derived for acute (24 hours), short-term ( and amp;gt;24 hours up to 30 days), and subchronic ( and amp;gt;30 days up to 10 percent of a lifetime) exposure durations, all of which are derived based on an assumption of continuous exposure throughout the duration specified. Unless specified otherwise, the RfD and RfC are derived for chronic exposure duration. The carcinogenicity assessment provides information on the carcinogenic hazard potential of the substance in question and quantitative estimates of risk from oral and inhalation exposure may be derived. The information includes a weight-of-evidence judgment of the likelihood that the agent is a human carcinogen and the conditions under which the carcinogenic effects may be expressed.