Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
624921
Reference Type
Journal Article
Title
Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests
Author(s)
Shelby, MD; Witt, KL
Year
1995
Is Peer Reviewed?
Yes
Journal
Environmental and Molecular Mutagenesis
ISSN:
0893-6692
EISSN:
1098-2280
Volume
25
Issue
4
Page Numbers
302-313
Language
English
PMID
7607185
DOI
10.1002/em.2850250407
Web of Science Id
WOS:A1995RG03600006
Abstract
Tests for the induction of chromosomal aberrations (ABS) and micronuclei (MN) in bone marrow cells of mice have been conducted on 65 chemicals. Although these tests were not conducted with the purpose of comparing the outcomes of these two in vivo genetic toxicity endpoints, the availability of these test results permits such a comparison. Based on studies to date, results from the 2 tests agree for more than 80% of the chemicals; 17 gave positive results in both tests, and 36 gave negative results in both. Seven chemicals were positive only for ABS and 5 were positive only for MN. Three chemicals that were originally concluded to be positive for ABS but not for MN were found to induce MN when the MN protocol was modified to more closely reflect the ABS protocol. Among the 12 chemicals for which there are discrepant results, there are only 2 for which the difference is convincing. One of these, selenium sulfide (MN negative, ABS positive) remains an enigma; further studies are being conducted. The second, isoprene (MN positive, ABS negative) will be difficult to pursue because the studies reported here were done by inhalation exposure. Based on the outcomes of these comparisons, protocol factors, rather than endpoint specificity, appear to be the major source of discrepant test results. Thus, these results do not support a recommendation that both tests be conducted in a primary testing scheme for genetic toxicity.
Keywords
genetic toxicology; in vivo; cytogenetics
Tags
•
Chloroform 2018 Update
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Excluded Studies
Excluded, but considered supplemental information
•
Chloroform Combined (current)
Chloroform (original)
Chloroform (2018 update)
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Excluded Studies
Excluded, but considered supplemental information
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
•
Cobalt
Cobalt IAP/Protocol
Supplemental
References from Other Sources
NTP (2014) Cobalt Metal
•
1,2-Dibromo-3-chloropropane
Litsearch 2018
Toxline
PFAS
•
PFAS 150
Literature Search August 2019
ToxNet
11:1 Fluorotelomer alcohol
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity