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Citation
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HERO ID
597688
Reference Type
Journal Article
Title
Metabolic capacity of nasal tissue: Interspecies comparisons of xenobiotic-metabolizing enzymes
Author(s)
Thornton-Manning, JR; Dahl, AR
Year
1997
Is Peer Reviewed?
1
Journal
Mutation Research
ISSN:
0027-5107
EISSN:
1873-135X
Volume
380
Issue
1-2
Page Numbers
43-59
Language
English
PMID
9385389
DOI
10.1016/S0027-5107(97)00126-7
Web of Science Id
WOS:A1997YE98400007
Abstract
High levels of xenobiotic-metabolizing enzymes occur in the nasal mucosa of all species studied. In certain species, including rats and rabbits, unique enzymes are present in the nasal mucosa. The function of these enzymes is not well understood, but it is thought that they play a role in protecting the lungs from toxicity of inhalants. The observation that several nasal xenobiotic-metabolizing enzymes accept odorants as substrates may indicate that these enzymes also play a role in the olfactory process. Xenobiotic-metabolizing enzymes were found in the nasal cavity around 15 years ago. Since that time, much has been learned about the nature of the enzymes and the substrates they accept. In the present review, this information is summarized with special attention to species differences in xenobiotic-metabolizing enzymes of the nasal cavity. Such differences may be important in interpreting the results of toxicity assays in animals because rodents are apparently more susceptible to nasal toxicity after exposure to inhalants than are humans.
Keywords
Nasal metabolism; Olfactory mucosa metabolism; Nasal respiratory mucosa; Olfactory mucosa
Tags
•
Chloroform Combined (current)
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
•
Formaldehyde
Nervous system effects
Found
Database search results
Snowball search
Screened
Title/abstract
Related to endogenous processes or chemistry
Retroactive RIS import
Pre2013
Merged LitSearch Additions 86 Reviews SCREEN
Ref List Citations 101112
2013
HCHON tox Ref Identification 022713
•
Naphthalene
Additional strategies
Combined data set
Data set for title/abstract screening
Excluded - PECO criteria not met (TIAB)
Supplemental material
ADME/Toxicokinetics
•
Naphthalene (2021 Evidence mapping publication)
Additional strategies
Combined data set
Data set for title/abstract screening
Excluded – PECO criteria not met
Supplemental material
ADME/Toxicokinetics
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