US EPA

157419 

Journal Article 

Cancer incidence and mortality in a cohort of chloroprene workers from Armenia 

Bulbulyan, MA; Margaryan, AG; Ilychova, SA; Astashevsky, SV; Uloyan, SM; Cogan, VY; Colin, D; Boffetta, P; Zaridze, DG 

1999 

Yes 

International Journal of Cancer
ISSN: 0020-7136
EISSN: 1097-0215 

81 

1 

31-33 

English 

10077148 

10.1002/(SICI)1097-0215(19990331)81:1<31::AID-IJC6>3.0.CO;2-T 

WOS:000078963000006 

https://search.proquest.com/docview/17234070?accountid=171501
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We evaluated the risk of cancer among 1897 men and 417 women exposed to chloroprene (2-chloro-1,3-butadiene, CP) at a production plant in Yerevan, Armenia, between 1940 and 1988. The cohort was followed up for cancer incidence for the years 1979-1990 and for cancer mortality for 1979-1988. In the cohort, incidence and mortality from all cancers were below expectation, but increased incidence (standardized incidence ratio 3.27, 95% confidence interval [CI] 1.47-7.27), and mortality (standardized mortality ratio 3.39, 95% CI 1.09-10.5) from liver cancer were noticed. A dose-response relationship was suggested between liver cancer and indices of CP exposure, such as duration of employment, duration of high CP exposure and cumulative exposure to CP. The risk of other neoplasms was not increased. 

Armenia/epidemiology; Chloroprene/adverse effects; Follow-Up Studies; Incidence; Liver Neoplasms/chemically induced/epidemiology/mortality; Neoplasms/chemically induced/epidemiology/mortality; Occupational Diseases/chemically induced/epidemiology/mortality; 126-99-8