Journal Article
Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals
Zeiger, E; Anderson, B; Haworth, S; Lawlor, T; Mortelmans, K
Environmental and Molecular Mutagenesis
ISSN: 0893-6692
EISSN: 1098-2280
#311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented.
Ames test; National Toxicology Program; mutagenicity testing; Salmonella
