US EPA

94970 

Technical Report 

Mortality analysis of workers exposed to chloroprene (Final report for EI DuPont deNemours & Company) 

Leet, TL; Selevan, SG 

1982 

National Institute for Occupational Safety and Health; Center for Disease Control; Public Health Service; Department of Health and Human Services 

Cincinnati, OH 

A historical cohort mortality study of 1,575 men occupationally exposed to chloroprene was conducted by the medical division of E.I. duPont de Nemours and Company (DuPont). The study was designed to evaluate the risk of lung cancer and other major causes of mortality with respect to chloroprene exposure. The study showed no association between chloroprene exposure and an increased risk of mortality from specific diseases, including lung cancer (Pell, 1978).
The National Institute for Occupational Safety and Health (NIOSH) assisted DuPont in the study by providing additional epidemiologic resources. NIOSH was able to determine the vital status of 223 of 240 men in the cohort who could not be located by DuPont. This effort reduced the percentage of men lost to follow-up from 15.2% to 1.1%. 'Once the original study was completed, NIOSH was given the data by DuPont to reanalyze, using the NIOSH modified life table computer program. This report summarizes the results of the reanalysis.