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Citation
Tags
HERO ID
93236
Reference Type
Journal Article
Title
Testing for increased carcinogenicity using a survival-adjusted quantal response test
Author(s)
Portier, CJ; Bailer, AJ
Year
1989
Is Peer Reviewed?
Yes
Journal
Fundamental and Applied Toxicology
ISSN:
0272-0590
EISSN:
1095-6832
Volume
12
Issue
4
Page Numbers
731-737
Language
English
PMID
2744275
DOI
10.1016/0272-0590(89)90004-3
Web of Science Id
WOS:A1989U658400004
URL
http://toxsci.oxfordjournals.org/content/12/4/731.abstract
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Abstract
The linear trend test in proportions is frequently used to analyze the results of animal carcinogenicity experiments. This test has two major advantages over other frequently used tests; it is easily understood and it is simple to calculate. This test, however, fails to correct for treatment-related differences in survival across the experimental groups. A test which is a simple modification of the linear trend test in proportions and which has the same advantages is proposed to correct for differences in survival. The results of this modified test are compared to those of the linear trend test in proportions, the incidental tumor test, the logistic regression score test, the life table test, and the truncated trend test using information on the incidence of combined alveolar/bronchiolar adenomas or carcinomas in female B6C3F1 mice exposed to vinylcyclohexene diepoxide.
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
•
Cobalt
Cobalt IAP/Protocol
Exclude
References from Other Sources
NTP (2014) Cobalt Metal
•
Formaldehyde
Animal LHP studies
Cited
•
Methanol (Non-Cancer)
Ramazzini
•
Trichloroethylene (TCE) (Final, 2011)
All References
Dose-Response
Cancer
NAAQS
•
ISA-NOx (2016)
2008 Final
OPPT REs
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
Off topic
•
Ramazzini Institute
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