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Citation
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HERO ID
81080
Reference Type
Journal Article
Title
Acute blood pressure responses in healthy adults during controlled air pollution exposures
Author(s)
Urch, B; Silverman, F; Corey, P; Brook, JR; Lukic, KZ; Rajagopalan, S; Brook, RD
Year
2005
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Book Title
Environmental Health Perspectives
Volume
113
Issue
8
Page Numbers
1052-1055
Language
English
PMID
16079078
DOI
10.1289/ehp.7785
Web of Science Id
WOS:000230941100045
URL
http://www.ncbi.nlm.nih.gov/pubmed/16079078
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Abstract
Exposure to air pollution has been shown to cause arterial vasoconstriction and alter autonomic balance. Because these biologic responses may influence systemic hemodynamics, we investigated the effect of air pollution on blood pressure (BP). Responses during 2-hr exposures to concentrated ambient fine particles (particulate matter < 2.5 microm in aerodynamic diameter; PM2.5) plus ozone (CAP+O3) were compared with those of particle-free air (PFA) in 23 normotensive, nonsmoking healthy adults. Mean concentrations of PM2.5 were 147 +/- 27 versus 2 +/- 2 microg/m3, respectively, and those of O3 were 121 +/- 3 versus 8 +/- 5 ppb, respectively (p < 0.0001 for both). A significant increase in diastolic BP (DBP) was observed at 2 hr of CAP+O3 [median change, 6 mm Hg (9.3%); binomial 95% confidence interval (CI), 0 to 11; p = 0.013, Wilcoxon signed rank test] above the 0-hr value. This increase was significantly different (p = 0.017, unadjusted for basal BP) from the small 2-hr change during PFA (median change, 1 mm Hg; 95% CI, -2 to 4; p = 0.24). This prompted further investigation of the CAP+O3 response, which showed a strong association between the 2-hr change in DBP (and mean arterial pressure) and the concentration of the organic carbon fraction of PM2.5 (r = 0.53, p < 0.01; r = 0.56, p < 0.01, respectively) but not with total PM2.5 mass (r < or = 0.25, p > or = 0.27). These findings suggest that exposure to environmentally relevant concentrations of PM2.5 and O3 rapidly increases DBP. The magnitude of BP change is associated with the PM2.5 carbon content. Exposure to vehicular traffic may provide a common link between our observations and previous studies in which traffic exposure was identified as a potential risk factor for cardiovascular disease.
Keywords
air pollution; blood pressure; hypertension; ozone; particulate matter; PM2.5
Tags
•
ISA-Lead (2013 Final Project Page)
Considered
Health Effects
Atmospheric and Exposure Sciencies
•
ISA-Ozone (2013 Final Project Page)
Considered
Cited
1st Draft
2nd Draft
3rd Draft
Final
Atm/Exp Science
Health Effects
•
ISA-PM (2009 Final Project Page)
2009 Final
•
ISA-PM (2019)
1st Draft
Chapter 6
Final ISA
Chapter 6
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