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76133 
Technical Report 
Interim policy for particle size and limit concentration issues in inhalation toxicity studies 
U.S. Environmental Protection Agency :: U.S. EPA 
1994 
U.S. Environmental Protection Agency, Office of Pesticide Products 
Washington, DC 
21 
EPA is making available to all interested parties, an Interim Policy for Particle Size and Limit Concentration Issues in Inhalation Toxicity Studies which deals with several of the most controversial issues encountered in inhalation toxicity studies. It offers recommendations regarding aerosol particle size, limit concentrations in acute studies, revised Toxicity Categories, inhalation chamber selection, and reporting of analytical concentrations for formulations. 
• Biphenyl
     Considered
     Cited References
          Guidance
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Formaldehyde
     Retroactive RIS import
          Pre2013
               Formaldehyde IRIS 2011
                    Old references
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Cited in External Review Draft (2011)
• PCBs
     Cited (Nov 2012)
• Tetrachloroethylene (Perc) (Final, 2012)
     All References
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
• Vanadium Compounds - Problem Formulation
     Manual review of existing IRIS and PPRTV assessments
          IRIS 2011/2014
     Combined data set
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
• Vanadium Inhalation
     Combined Dataset
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
• Vanadium Pentoxide (Draft, 2011)
OPPT REs
• OPPT_1,4-Dioxane_C. Engineering
     Data screening total
          Screening: Excluded
• OPPT_1,4-Dioxane_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          Off topic