Health & Environmental Research Online (HERO)


Print Feedback Export to File
699585 
Journal Article 
Aflatoxin and trichothecene toxins: Skin tumor induction and synergistic acute toxicity in white mice 
Lindenfelser, L; Lillehoj, E; Burmeister, H 
1974 
Yes 
Journal of the National Cancer Institute
ISSN: 0027-8874
EISSN: 1460-2105 
HEEP/75/00068* 
52 
1 
113-116 
English 
4855757 
HEEP COPYRIGHT: BIOL ABS. Toxic interactions of 3 naturally occurring mycotoxins were examined by the mouse skin tumor test and acute toxicity trials. Aflatoxin B1 (B1) functioned as a tumor-initiating substance. A single 25-mug dose applied before croton oil as promoter caused papilloma formation on more than 1/2 the test animals. Neither Fusarium toxin, T-2 toxin (T-2) or diacetoxyscirpenol served as initiating agents. These 2 mycotoxins acted as weak promoter substances on 7,12-dimethylbenz(a)anthracene (DMBA)-initiated mouse skin cells but not on mice treated with B1 as initiator. Either DMBA or B1 initiation followed by T-2 promotion (25 mug/dose) caused extensive skin damage and subsequent tolerance of the treated skin to elevated doses of T-2. In acute toxicity trials, combinations of B1 and T-2 produced a synergistic lethal response.