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667208 
Book/Book Chapter 
Draft revised guideline 203: Fish, acute toxicity test 
Organisation for Economic Co-operation and Development :: OECD 
1992 
OECD Publishing 
OECD Guideling for testing of chemicals 
OECD Guidelines for Testing of Chemicals are periodically reviewed to ensure that they reflect the best available science. In the revision of this Guideline (originally adopted in 1981, updated in 1984 and 1992), special attention was given to possible improvements in relation to animal welfare concerns in order to avoid unnecessary testing in laboratory animals. According to this updated version of Guideline 203, prior to undertaking the described fish acute toxicity test it should be evaluated whether the Threshold Approach provided as Annex 2 to this guideline is applicable. The Threshold Approach takes into consideration EC50 values from relevant algae and acute invertebrate (e.g. daphnia) tests. 
11/17/2010