Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

64961

Reference Type

Journal Article

Title

Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat

Author(s)

Summer, KH; Greim, H

Year

1980

Is Peer Reviewed?

Yes

Journal

Biochemical and Biophysical Research Communications
ISSN: 0006-291X
EISSN: 1090-2104

Volume

Issue

Page Numbers

566-573

Language

English

PMID

7425999

DOI

10.1016/0006-291X(80)91393-5

Web of Science Id

WOS:A1980KK77400006

URL

http://www.sciencedirect.com/science/article/pii/0006291X80913935
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Abstract

Biotransformation of chloroprene (2-chloro-1,3-butadiene) in the rat or in isolated rat hepatocytes leads to glutathione conjugates with concomitant depletion of hepatic glutathione and increased excretion rates of urinary thioethers. Conjugate formation depends on microsomal enzyme activities suggesting the involvement of an epoxide intermediate.

GSH, reduced glutathione; GSSG, oxidized glutathione; DTNB, 5,5′-dithio-bis(2-nitrobenzoic acid); LDH, lactatedehydrogenase

Keywords

Animals; Butadienes/metabolism; Chloroprene/metabolism/toxicity; Glutathione/metabolism; In Vitro Techniques; Inactivation, Metabolic; L-Lactate Dehydrogenase/metabolism; Liver/metabolism; Sulfides/urine; 126-99-8