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64560 
Technical Report 
EPA Report 
Recommendations for and documentation of biological values for use in risk assessment 
U.S. Environmental Protection Agency :: U.S. EPA 
1988 
Yes 
U.S. Environmental Protection Agency 
Cincinnati, OH 
EPA600687008 
English 
The document was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response. The document consists of an extensive compilation of values gleaned from published literature sources for lifespan, body weight, food consumption, water consumption and inhalation volumes for a wide range of predominately mammalian species.

Synthesis of the information to provide recommendations concerning parameters for conversion of exposure data (drinking water, food and air concentration) from mammalian toxicological studies to dose estimates in units of milligrams/kilogram body weight/day is provided. 
PB88179874 
• Ammonia
     Literature Search – March 2012 (private)
     Literature Search Results
     Not Chemical Specific
          Guidance, notices
• Ammonia, Oral - Problem Formulation
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
• Biphenyl
     Considered
     Cited References
          Animal studies
               Oral subchronic and chronic
               Reproductive and developmental
               Urinary tract endpoint studies
          Other studies
               Dose-response assessment
          Guidance
• tert-Butanol
     Cited in Document
• n-Butanol
     • Cited 2016 Public Comment Draft
          Tox Review
          Supplementary Materials
• tert-Butanol
     Cited in Public Comment Draft – May 2016
          Toxicological Review
• Chloroform Combined (current)
     Chloroform (original)
     Chloroform (current)
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• Chromium VI
     Cited in Document
• Cobalt
     References from Other Sources
          PPRTV
• DCM (Dichloromethane) (Final, 2011)
• Dibutyl Phthalate (DBP)
     Studies with Health Effects Data
          Animal toxicology studies
• Diisobutyl Phthalate (DIBP) Final
     Additional Search Strategies
          References obtained during assessment process
     No Primary Data on Toxic Effects
          Not chemical specific
     Cited in September 2014 DIBP Preliminary Materials
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• ETBE
     Cited in Document
     Not in Lit Search
• Ethylbenzene
     Protocol template references
• Hexabromocyclododecane (HBCD)
     Additional Search Strategies
     Secondary Literature
• Inorganic Mercury Salts (2)
     Litcite References – Protocol
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Cited in External Review Draft (2011)
• Naphthalene
• Nitrate/Nitrite
     Other resources cited in assessment
• PCBs
     Supplemental
     Cited (Nov 2012)
     IRIS assessment protocol template
     Seed References
• RDX (121-82-4)
     Cited 2015 (private)
• Tetrachloroethylene (Perc) (Final, 2012)
     All References
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Dose-Response
     Non-Cancer
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Uranium Toxicological Review
     Additional Strategies
• Vanadium Compounds - Problem Formulation
     Manual review of existing IRIS and PPRTV assessments
          IRIS 2011/2014
          PPRTV 2009
     Combined data set
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
• Vanadium Inhalation
     Combined Dataset
          Dataset for title/abstract screening
               Excluded- PECO criteria not met (TIAB)
     Cited in Protocol
• Vanadium Pentoxide (Draft, 2011)
OPPT REs
• OPPT_1,4-Dioxane_C. Engineering
     Data screening total
          Screening: Excluded
• OPPT_1,4-Dioxane_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_1,4-Dioxane_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Carbon Tetrachloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
     Data screening total
          Screening: Excluded
• OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
     Total – title/abstract screening
          On topic
               Peer review
                    Secondary source/Review
• OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Methylene Chloride_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          Off topic
PFAS
• PFBA
     Protocol References
     Supplemental References
• PFBS
     Included
          Supporting References
• PFDA
• PFHxS