US EPA

62933 

Journal Article 

Three industrial solvents investigated for tumor promoting activity in the rat liver 

Lundberg, I; Hogberg, J; Kronevi, T; Holmberg, B 

1987 

Yes 

Cancer Letters
ISSN: 0304-3835
EISSN: 1872-7980 

NIOSH/00171944 

Cancer Letters 

36 

1 

29-33 

English 

2884030 

10.1016/0304-3835(87)90099-1 

https://linkinghub.elsevier.com/retrieve/pii/0304383587900991
Exit
 

Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosoamine, 30 mg/kg, injected i.p. 24 h after Image partial hepatectomy. The chemical under study was administered by gavage once a day, 5 times a week for 7 weeks. Ten days after the last administration the animals were killed. Liver sections were stained for γ-glutamyltranspeptidase (GGT) and the number and total volume of GGT-positive foci was studied. Dioxane (1000 mg/kg) significantly increased the number and total volume of foci while a marginal effect was noted for the high dose of trichloroethylene (1100 mg/kg). A high dose of perchloroethylene (1100 mg/kg) had no effect. 

Administration; Oral Animals Carcinogens Diethylnitrosamine toxicity Dioxanes toxicity Dioxins toxicity Injections; Intraperitoneal Liver drug effects Liver metabolism Male Rats Rats; Inbred Strains Tetrachloroethylene toxicity Trichloroethylene toxicity gamma-Glutamyltransferase metabolism Index Medicus