Induction of carcinomas in the nasal cavity of rats by dioxane | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

62926

Reference Type

Journal Article

Title

Induction of carcinomas in the nasal cavity of rats by dioxane

Author(s)

Hoch-Ligeti, C; Argus, MF; Arcos, JC

Year

1970

Is Peer Reviewed?

Yes

Journal

British Journal of Cancer
ISSN: 0007-0920
EISSN: 1532-1827

Book Title

British journal of cancer

Volume

Issue

Page Numbers

164-167

Language

English

PMID

4316974

URL

https://www.proquest.com/scholarly-journals/induction-carcinomas-nasal-cavity-rats-dioxane/docview/84648158/se-2?accountid=171501
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Abstract

Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition.

Keywords

Adenocarcinoma/chemically induced; Animals; Carcinoma, Hepatocellular/chemically induced; Carcinoma, Squamous Cell/*chemically induced/pathology; *Dioxins; Liver Neoplasms; Male; Neoplasms, Experimental/chemically induced/pathology; Nose Neoplasms/*chemically induced/pathology; Papilloma/chemically induced; Rats

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