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62924 
Journal Article 
Teratogenesis study of dioxane in rats 
Giavini, E; Vismara, C; Broccia, ML 
1985 
1 
Toxicology Letters
ISSN: 0378-4274
EISSN: 1879-3169 
Elsevier 
Toxicol. Lett. 
26 
1 
85-88 
English 
4024160 
WOS:A1985APJ7100014 
The industrial solvent dioxane (1,4-diethylene dioxide) was evaluated for teratogenic potential in Sprague-Dawley rats. The compound was administered on days 6-15 of gestation by gavage (0, 0.25, 0.5 and 1.0 ml/kg/day). A slight maternal toxicity, as evidenced by reduced weight gain, was observed with 1.0 ml/kg. Animals were killed and subjected to uterine examination on day 21 of pregnancy. There were no differences between control and dioxane-treated groups in implantation numbers, live fetuses, postimplantation loss or major malformations. Embryotoxicity, manifested by reduced fetal weight, occurred only at the highest dose level. 
Dioxane; rat; embryotoxicity; teratogenicity 
IRIS
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Dioxin (2012 Project Page for Final Report)
• Formaldehyde
     Reproductive and Developmental Effects
          Screened
               Title/abstract
                    Not formaldehyde
     Retroactive RIS import
          2015
               FA DevRepro 072115
                    Not FA-Exposure Criteria
                         Not FA-Exposure Criteria
OPPT REs
• OPPT_1,4-Dioxane_D. Exposure
     Total – title/abstract screening
          Supplemental Search
• OPPT_1,4-Dioxane_F. Human Health
     Total – title/abstract screening
          On topic
               Peer review
                    Primary source
               Cited in IRIS document or IRIS HERO page
     On topic - additional tags for titles/abstracts
          Animal hazard ID