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Citation
Tags
HERO ID
62919
Reference Type
Journal Article
Title
The toxicity to animals of 1:4 dioxan
Author(s)
Fairley, A; Linton, EC; Ford-Moore, AH
Year
1934
Is Peer Reviewed?
Yes
Journal
Journal of Hygiene
ISSN:
0022-1724
Book Title
The Journal of hygiene
Volume
34
Issue
4
Page Numbers
486-501
Language
English
PMID
20475249
DOI
10.1017/S0022172400043266
URL
https://www.cambridge.org/core/product/identifier/S0022172400043266/type/journal_article
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Abstract
Rabbit 1 and mouse 1 probably died from pneumonia, although, both animals showed well-marked lesions in both liver and kidneys. The rat lungs were—as usual—dubious. In the other animals the lungs were normal and the picture was one of hepatic and renal damage alone.
At this concentration, the likelihood of pulmonary affections, and death therefrom, appears to be much less than in the cases of animals exposed to 1/100.
Pulmonary inflammation does not occur at this concentration, and the lesions were exclusively hepatic and renal.
Summary: Pulmonary inflammation does not occur at this concentration, and the lesions were exclusively hepatic and renal.
Summary: The rats in the experiment seemed to be more severely affected than the mice, and two rats died with an acute enteritis. The renal and hepatic tissue changes were also more severe in the rats.
Tags
IRIS
•
1,4-Dioxane - with inhalation update
Final (2013)
External Review Draft (2011)
OPPT REs
•
OPPT_1,4-Dioxane_D. Exposure
Total – title/abstract screening
Supplemental Search
•
OPPT_1,4-Dioxane_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
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