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628495 
Journal Article 
Review 
A review of the epidemiology of 1,3-butadiene and chloroprene 
Acquavella, JF; Leonard, RC 
2001 
Yes 
Chemico-Biological Interactions
ISSN: 0009-2797
EISSN: 1872-7786 
ELSEVIER SCI IRELAND LTD 
CLARE 
135-136 
43-52 
English 
11397380 
WOS:000170881000004 
Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene-butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefully enumerated study populations, extremely long and high quality mortality follow-up, accurate job categorizations, detailed exposure assessments, and comprehensive statistical analyses. Leukemia was clearly associated with increasing estimated butadiene exposure in the SBR study, but not in the monomer industry study. This has lead to hypotheses about exposure differences between these two industries and the presence of co-factors or confounders in the SBR industry. Research presented at this symposium should shed some light on these hypotheses. The chloroprene epidemiologic literature, on the other hand, is in an early stage of development. The existing studies are limited by poor exposure characterization, lack of control of potential confounding factors, incompleteness in cohort enumeration, short follow-up periods, and small numbers of cancer cases. The state of the science for chloroprene would be advanced by arranging more comprehensive studies than those that have been conducted to date. 
Styrene-butadiene rubber; Leukemia; Chloroprene; Cohort 
38th European Congress of Toxicology 
LONDON, ENGLAND 
IRIS
• Chloroprene
     Cited 2010 Final - Appendix A Only
     Not Cited