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Citation
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HERO ID
626019
Reference Type
Journal Article
Title
Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1
Author(s)
Shelef, LA; Chin, B
Year
1980
Is Peer Reviewed?
Yes
Journal
Applied and Environmental Microbiology
ISSN:
0099-2240
EISSN:
1098-5336
Report Number
EMICBACK/41012
Volume
40
Issue
6
Page Numbers
1039-1043
Language
English
PMID
7458309
DOI
10.1128/aem.40.6.1039-1043.1980
URL
http://aem.asm.org/cgi/content/abstract/40/6/1039
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Abstract
The Ames assay employing Salmonella typhimurium TA100 and TA98 was used to investigate potential interactions between aflatoxin B1 (AFB1) and the phenolic antioxidants butylated hydroxytoluene, butylated hydroxyanisole, and propyl gallate. AFB1 doses were within the linear response range, and the antioxidants were used at levels of 0 to 50 micrograms per plate. All three antioxidants were nonmutagenic in either bacterial tester strain, with or without the hepatic S-9 enzyme preparation; toxic effects were observed at doses higher than 20 micrograms per plate. Butylated hydroxytoluene and butylated hydroxyanisole substantially increased AFB1-induced mutagenesis in the two tester strains with microsomal activation. The addition of 5 to 20 micrograms of butylated hydroxytoluene or hydroxyanisole to 5 to 20 ng of AFB1 per plate caused more than a twofold increase in the number of His+ revertants. Addition of propyl gallate resulted in only a moderate increase in the number of revertants. Whereas several anticarcinogenic and antimutagenic effects by phenolic antioxidants have been reported, particularly in studies with polycyclic aromatic hydrocarbons, the enhancement of mutagenic potency of AFB1 by these compounds suggests a specificity with respect to the chemical nature of AFB1.
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IRIS
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PCBs
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