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626004 
Journal Article 
Radiosensitization of Drosophila sperm by commonly used food additives - butylated hydroxyanisole and butylated hydroxytoluene 
Prasad, O; Kamra, OP 
1974 
Yes 
International Journal of Radiation Biology
ISSN: 0955-3002
EISSN: 1362-3095 
Informa Healthcare 
25 
1 
67-72 
English 
4543817 
WOS:A1974R753200007 
The radiosensitivity of sperm of Drosophila melanogaster was enhanced by a factor of about two by commonly-used food additives. Neither butylated hydroxyanisole (BHA) nor butylated hydroxytoluene (BHT), with and without gamma-irradiation (0, 1·2, 2·4 and 3·6 krads), had any noticeable effect on the sex-ratio. At the concentration used (0·001 per cent BHA; 0·001 per cent BHT), the two phenolic antioxidants seem to induce XB-chromosome loss in the sperm (XO males in F1) and sex-linked recessive lethal mutations in F2, although these effects were not statistically significant. However, both agents proved to be potent radiosensitizers for the sex-linked recessive lethals.