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625999 
Journal Article 
Inhibition of promutagen activation by the antioxidants butylated hydroxyanisole and butylated hydroxytoluene 
Mckee, RH; Tometsko, AM 
1979 
Yes 
Journal of the National Cancer Institute
ISSN: 0027-8874
EISSN: 1460-2105 
NATL CANCER INSTITUTE 
BETHESDA 
63 
2 
476-477 
English 
287836 
WOS:A1979HJ86700033 
Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) exhibited antimutagenic activity in the Salmonella typhimurium reversion test. Both BHA and BHT reduced reversion induced by chemicals requiring metabolic activation for effectiveness. However, they did not affect reversion induced by direct-acting mutagens. These results suggested that BHA and BHT may inhibit the metabolic activation processes and demonstrated that the S. typhimurium reversion test may be used to identify inhibitors of the neoplastic process.