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Citation
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HERO ID
625901
Reference Type
Journal Article
Title
Mutagenicity studies of different polycyclic aromatic hydrocarbons the significance of enzymatic factors and molecular structure
Author(s)
Pahlman, R; Pelkonen, O
Year
1987
Is Peer Reviewed?
Yes
Journal
Carcinogenesis
ISSN:
0143-3334
EISSN:
1460-2180
Report Number
BIOSIS/87/24873
Volume
8
Issue
6
Page Numbers
773-778
Language
English
PMID
3301044
URL
http://carcin.oxfordjournals.org/cgi/content/abstract/8/6/773
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Abstract
Dependence of polycyclic aromatic hydrocarbon (PAH)-induced mutagenicity on the bay region of the molecule and on the activating cytochrome P-450 enzyme was studied. Eleven PAHs with and six without a bay region were activated by postmitochondrial supernatants from control and 3-methykholanthrene (MC)-pretreated C57BL/6 mice and from control, MC- and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-pretreated DBA/2 mice and from control and MC-pretreated Sprague-Dawley and Lewis rats. S-9 fractions from MC- or TCDD-treated animals induced more mutagenicity with PAHs with a bay region compared with S-9 fractions from control animals or MC-treated D2 mice. Mutagenicities of PAHs without a bay region were largely independent of the source of activating enzyme. There were three exceptions, namely benzo[e]pyrene, phenanthrene and perylene (each possessing a bay region), which were not mutagenic. These studies support the notion that the Ah-Jocus-controlled induction of cytochrome P1-450 activating PAHs into reactive intermediates at the bay region of the hydrocarbon molecule is of prime importance in the mutagenicity of PAHs. Qualitative correspondence to carcinogenicity is also apparent.
Keywords
Cytology and Cytochemistry-Animal
;
Genetics and Cytogenetics-Animal
;
Biochemical Studies-General
;
Biophysics-Molecular Properties and Macromolecules
;
Enzymes-Physiological Studies
;
Toxicology-General
;
Neoplasms and Neoplastic Agents-Biochemistry
;
Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis
;
Muridae
Tags
•
Benzo(a)pyrene (BaP)
Considered
Cited
Genotoxicity
•
Naphthalene
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•
Naphthalene (2021 Evidence mapping publication)
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Combined data set
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Excluded – PECO criteria not met
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