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HERO ID
625294
Reference Type
Journal Article
Title
Chronic toxicity Of butylated hydroxytoluene in Wistar rats
Author(s)
Hirose, M; Shibata, M; Hagiwara, A; Imaida, K; Ito, N
Year
1981
Is Peer Reviewed?
1
Journal
Food and Cosmetics Toxicology
ISSN:
0015-6264
EISSN:
1878-6049
Volume
19
Issue
2
Page Numbers
147-151
Language
English
PMID
7286863
DOI
10.1016/0015-6264(81)90350-3
Web of Science Id
WOS:A1981LR13300001
Abstract
Groups of 57 Wistar rats of each sex were maintained on diet containing 0.25 or 1% butylated hydroxytoluene (BHT) for 104 wk; control groups comprised 36 rats of each sex. Treated rats of both sexes showed reduced body-weight gain, relative spleen weight and white-blood-cell count while in the males there was also a reduction in serum triglyceride. BHT-treated animals of both sexes showed increased relative liver weight and total blood cholesterol but increases in red-blood-cell count could be seen only in females and only the males showed increased γ-glutamyltransferase. No significant histological changes were observed in the liver or haematopoietic system to explain these haematological and biochemical changes. Tumours were found in the liver, pancreas, mammary glands, uterus, pituitary gland, adrenal glands and in some other organs of some of the treated rats, but their incidence was not significantly different from that in controls. This experiment showed no carcinogenic effect of BHT on rats.
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