US EPA

5661097 

Journal Article 

Isoprene, an endogenous hydrocarbon and industrial chemical, induces multiple organ neoplasia in rodents after 26 weeks of inhalation exposure 

Melnick, RL; Sills, RC; Roycroft, JH; Chou, BJ; Ragan, HA; Miller, RA 

1994 

Yes 

Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 

54 

20 

5333-5339 

English 

7923161 

WOS:A1994PL55800015 

http://cancerres.aacrjournals.org/cgi/content/abstract/54/20/5333
Exit
 

BIOSIS COPYRIGHT: BIOL ABS. Isoprene, the 2-methyl analogue of 1,3-butadiene, is a high production chemical used largely in the manufacture of synthetic rubber and is the major endogenous hydrocarbon exhaled in human breath. Thirteen-week inhalation toxicology studies of isoprene were conducted in male and female F344 rats and B6C3F1 mice at exposure concentrations of 0, 70, 220, 700, 2200, and 7000 ppm (6 h/day; 5 days/week). In addition, 26-week inhalation studies at the same exposure levels. followed by a 26-week recovery period, were conducted in male rats and mice. The 13-week exposures produced no discernible exposure-related toxic effects in rats. Interstitial cell hyperplasia of the testis was observed in all male rats in the 7000 ppm group after 26 weeks of exposure-, following the 26-week recovery period the only effect in rats was a marginal increase in benign testicular interstitial cell tumors. In mice, isoprene induced toxic and carcinogenic effects at multiple organ sites. Following 

Butadienes; Hemiterpenes; Pentanes; isoprene; 0A62964IBU; Index Medicus; Harderian Gland -- drug effects; Testis -- drug effects; Stomach Neoplasms -- chemically induced; Rats, Inbred F344; Administration, Inhalation; Liver Neoplasms, Experimental -- chemically induced; Animals; Time Factors; Hyperplasia -- chemically induced; Testis -- pathology; Sex Factors; Lung Neoplasms -- chemically induced; Neoplasms, Multiple Primary -- pathology; Butadienes -- toxicity; Adenoma -- pathology; Adenoma -- chemically induced; Carcinoma -- chemically induced; Neoplasms, Multiple Primary -- chemically induced; Carcinoma -- pathology; Butadienes -- administration & dosage