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Citation
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HERO ID
625207
Reference Type
Journal Article
Title
Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice
Author(s)
Melnick, RL; Elwell, MR; Roycroft, JH; Chou, BJ; Ragan, HA; Miller, RA
Year
1996
Is Peer Reviewed?
1
Journal
Toxicology
ISSN:
0300-483X
EISSN:
1879-3185
Volume
108
Issue
1-2
Page Numbers
79-91
Language
English
DOI
10.1016/0300-483X(95)03286-O
URL
https://www.proquest.com/scholarly-journals/toxicity-inhaled-chloroprene-2-chloro-1-3/docview/77980605/se-2?accountid=171501
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Abstract
Chloroprene (2-chloro-1,3-butadiene) is a high production chemical used almost exclusively in the production of polychloroprene (neoprene) elastomer. Because of its structural similarity to isoprene (2-methyl-l,3-butadiene) and to 1,3-butadiene, a potent trans-species carcinogen, inhalation studies were performed on chloroprene to characterize its lexicological potential and to provide a basis for selecting exposure concentrations for chronic toxicity and carcinogenicity studies. Thirteen-week inhalation toxicology studies were conducted in male and female F344 rats and B6C3F1 mice at exposure concentrations of 0, 5,12, 32 or 80 ppm (6 h/day; 5 days/week). A 200 ppm exposure group was also included for rats only, because a previous study showed that this concentration of chloroprene is lethal to mice. In mice, exposure to 80 ppm chloroprene caused a marginal decrease in body weight gain in males and epithelial hyperplasia of the forestomach in males and females. This lesion has been observed in mice exposed to isoprene or 1,3-butadiene. In rats, exposure to 80 ppm chloroprene or higher concentrations caused degeneration and metaplasia of the olfactory epithelium and exposure to 200 ppm caused anemia, hepatocellular necrosis and reduced sperm motility. These lesions have not been observed in rats exposed to isoprene or 1,3-butadiene. The profile of toxic effects of chloroprene is considerably different from that of isoprene or 1,3-butadiene; this may be due to differences in exposure concentrations that were used in toxicology studies of these compounds and/or to the influence of the chlorine substitution on the toxicokinetics of these compounds, on their biotransformation, or on the reactivity of metabolic intermediates with tissue macromolecules.
Keywords
Chloroprene; Butadiene; Inhalation toxicology; Hepatocellular necrosis; Anemia; Olfactory epithelial degeneration
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
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