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HERO ID
625174
Reference Type
Journal Article
Subtype
Review
Title
Pros and cons of transgenic mouse mutagenesis test systems
Author(s)
Gahlmann, R
Year
1993
Is Peer Reviewed?
Yes
Journal
Journal of Experimental Animal Science
ISSN:
0939-8600
Volume
35
Issue
5-6
Page Numbers
232-243
Language
English
PMID
8218438
Abstract
Over the last two years, first results of transgenic mouse mutagenicity assays have appeared in the literature. If sufficiently sensitive, this new in vivo transgenic mouse assay may be the first approach that allows us to measure frequencies of induced point mutations for any suspected target organ in mice. It may also be useful as a routine assay and could complement or replace the mouse spot test or the specific locus test. Different transgenic mouse strains exist that can be employed for this assay. This review summarizes some of the data that were generated with this promising novel in vivo test system. Remaining problems with its sensitivity and the question of the optimal test protocol are discussed.
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
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