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625123 
Journal Article 
Mutagenicity of substituted anthraquinones in the Ames/Salmonella microsome system 
Krivobok, S; Seigle-Murandi, F; Steiman, R; Marzin, DR; Betina, V 
1992 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
EMIC/87300 
279 
1 
1-8 
English 
1374527 
Unsubstituted anthraquinone, 4 substituted anthraquinones (emodin, danthron, physcion, a new compound M-108-C) and 3 dimers (skyrin, rugulosin, rugulin) were tested using the Ames/Salmonella assay (strains TA98, TA100, TA1537 and TA102). Danthron and emodin were found to be mutagenic for TA1537 with or without metabolic activation, physcion only with metabolic activation. A significant difference was found between the mutagenic activities of emodin (16.2 His+/nmole) and danthron (6.5 His+/nmole) as well as a high specific mutagenic activity for physcion (11.6 His+/nmole). These results on structure-mutagenic activity relationships suggest that the 6-methyl group plays an important role in the mutagenic activity after metabolic activation. Furthermore, and contrary to emodin, physcion exhibited a weak mutagenic activity for TA102, probably due to the formation of a different metabolite. Such information is necessary to evaluate the potential carcinogenic hazard of these compounds. 
Anthraquinones; Mutagenesis; Ames test