Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

625117

Reference Type

Journal Article

Title

Toxicity studies of butylated hydroxyanisole and butylated hydroxytoluene. II. Chronic feeding studies

Author(s)

Williams, GM; Wang, CX; Iatropoulos, MJ

Year

1990

Is Peer Reviewed?

Yes

Journal

Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351

Volume

Issue

Page Numbers

799-806

Language

English

PMID

2276703

DOI

10.1016/0278-6915(90)90052-O

Web of Science Id

WOS:A1990EV59500002

Abstract

The antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were fed in the diet to male F344 rats in two chronic feeding studies. In one study, feeding BHT for 76 wk at concentrations ranging from 100 to 6000 ppm produced no increase in neoplasms at any site. In a second study, feeding 12,000 ppm BHT for 110 wk had no neoplastic effect at any site, whereas feeding BHA at 12,000 ppm resulted in a small increase in squamous cell papillomas of the non-glandular squamous portion of the stomach.