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Citation
Tags
HERO ID
625004
Reference Type
Journal Article
Title
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene
Author(s)
Ton, TV; Hong, HH; Devereux, TR; Melnick, RL; Sills, RC; Kim, Y
Year
2007
Is Peer Reviewed?
Yes
Journal
Chemico-Biological Interactions
ISSN:
0009-2797
EISSN:
1872-7786
Book Title
Chem Biol Interact.
Volume
166
Issue
1-3
Page Numbers
112-120
Language
English
PMID
16860786
DOI
10.1016/j.cbi.2006.04.015
Web of Science Id
WOS:000246096600013
URL
http://www.sciencedirect.com/science/article/pii/S0009279706001001
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Abstract
1,3-Butadiene and chloroprene are multisite carcinogens in B6C3F1 mice with the strongest tumor response being the induction of lung neoplasms in females. Incidence of brain tumors in mice exposed to 1,3-butadiene was equivocal. This article reviews the efforts of our laboratory and others to uncover the mechanisms of butadiene and chloroprene induced lung and brain tumor responses in the B6C3F1 mouse. The formation of lung tumors by these chemicals involved mutations in the K-ras cancer gene and loss of heterozygosity in the region of K-ras on distal chromosome 6, while alterations in p53 and p16 were implicated in brain tumorigenesis.
Keywords
1,3-Butadiene; Chloroprene; Brain; Lung; Tumor
Tags
IRIS
•
Chloroprene
Cited 2009 Draft
Cited 2010 Final
•
Mouse Lung Tumor Workshop 2014
Cited
Session 4 – Cellular & Subcellular Events
Molecular toxicology
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