US EPA

624981 

Journal Article 

The cytogenetic evaluation of in vivo genotoxic and cytotoxic activity using rodent somatic cells 

Tice, RR 

1988 

Yes 

Cell Biology and Toxicology
ISSN: 0742-2091
EISSN: 1573-6822 

Cell Biol Toxicol. 

4 

4 

475-486 

English 

3228715 

10.1007/bf00117775 

WOS:A1988R697400009 

https://search.proquest.com/docview/78675676?accountid=171501
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With the growing realization that in vitro short-term tests for genotoxicity can never fully mimic in vivo conditions, the evaluation of genotoxic damage in somatic cells of rodents has played an increasingly important role in assessing the carcinogenic potential of suspect compounds. Among the various genotoxic endpoints assessed in in vivo somatic cell assays, cytogenetic endpoints (e.g., chromosomal aberrations, micronuclei, sister chromatid exchanges) continue to be used most frequently. The purpose of this paper is to demonstrate the utility of evaluating different cytogenetic endpoints in the same animal, using as examples studies to evaluate the in vivo genotoxic potential of benzene, of methylisocyanate, and of butadiene, chloroprene and isoprene. 

benzene; butadiene; chloroprene; cytogenetic endpoint; isoprene; methylisocyanate; somatic cells