Tests for trend in life table analysis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

624959

Reference Type

Journal Article

Title

Tests for trend in life table analysis

Author(s)

Tarone, RE

Year

1975

Is Peer Reviewed?

Yes

Journal

Biometrika
ISSN: 0006-3444
EISSN: 1464-3510

Volume

Issue

Page Numbers

679-690

DOI

10.1093/biomet/62.3.679

URL

http://www.jstor.org/stable/2335528
Exit

Abstract

Using the regression model proposed by Cox (1972) a test for monotone trend in hazard functions is derived for use, for example, in chemical carcinogenesis experiments in which a chemical is administered at increasing dose levels. It is demonstrated that under the null hypothesis of no dose-response relationship the test statistic is distributed asymptotically as chi-squared with one degree of freedom. An exact test for trend is proposed which is valid when censorship is random and equal.

Keywords

Hazard function; Life table; Log rank teat; Monte Carlo simulation; Random censorship model