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Citation
Tags
HERO ID
58559
Reference Type
Journal Article
Title
The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays
Author(s)
Bruce, WR; Heddle, JA
Year
1979
Is Peer Reviewed?
Yes
Journal
Canadian Journal of Genetics and Cytology
ISSN:
0008-4093
Report Number
EMICBACK/31926
Volume
21
Issue
3
Page Numbers
319-333
Language
English
PMID
393369
DOI
10.1139/g79-036
Web of Science Id
WOS:A1979HS83600004
URL
http://
://WOS:A1979HS83600004
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Abstract
A comparison of two rapid and inexpensive in vivo mammalian assays and the Ames Salmonella assay is presented for 61 agents; Acetylsalicylic acid; Acriflavine; Actinomycin D; 2(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2); Aflatoxin B1; 2-aminofluorene; Aminopterin; Aroclor 1254; Ascorbic acid; Azathioprine; Benzo(a)pyrene; 5-Bromo-2'-deoxyuridine; Busulphan, Butylated hydroxytoluene; Cadmium chloride; Caffeine; Calcium cyclamate; Chloral hydrate; Chloromycetin succinate; Codeine phosphate, Colchicine; Cycloheximide; Cyclophosphamide; DDT; 2,4-Diaminoanisole; Dibutylnitrosamine; 9, 10 Dimethyl-1,2-benzanthracene; 1,1-Dimethylhydrazine; Dimethylnitrosamine; Epinephrine; Ethyl methane sulphonate (EMS); 2-formylamino-4-(5-nitro-2-furyl)thiazole (FANFT); 2-(2-formylhydrazino)-4-(5-nitro-2-furyl)thiazole (FNT); Glucose, Griseofulvin; Hycanthone methane sulphonate; Hydroxyurea; 5-Iodo-2'-deoxyuridine; Lead acetate; Mechlorethamine; 3-Methylcholanthrene; Methyl mercury acetate; Methyl methane sulfonate (MMS); N-methyl-N-nitro-N'-nitrosoguanidine; Mitomycin C; Monosodium glutamate; 1-Naphthalamine; 2-Naphthalamine; Nitrofurazone; 4-Nitro-O-phenylene diamine; 4-Nitro-quinoline-1-oxide (4-NQO); Phenobarbitone; Procarbazine; Quinacrine dihydrochloride; Radiation (gamma-rays); Sodium chloride; Triethylene thiophosphoramide; Trimethyl phosphate; Tris(2-methyl-1-arizidinyl) phosphine oxide; Urethan; Vinblastine. The results support the concept of multiple assays for mutagenicity and show that some combinations of assays are superior to others.
Tags
IRIS
•
Benzo(a)pyrene (BaP)
Considered
Cited
Genotoxicity
•
Formaldehyde
Reproductive and Developmental Effects
Screened
Title/abstract
Not developmental/reproductive
Retroactive RIS import
2015
FA DevRepro 072115
Not Dev/Repro-Outcome Criteria
Not Dev/Repro-Outcome Criteria
•
PCBs
Litsearches
PubMed
ToxLine
Initial Filter
Non Peer-Reviewed
LitSearch August 2015
Pubmed
Toxline
Cited (Nov 2012)
Restored references_April 2024
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