NTP technical report on toxicity studies of ethylene glycol ethers: 2-Methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol (CAS Nos 109-86-4, 110-80-5, 111-76-2) administered in drinking water to F344/N rats and B6C3F1 mice | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

42063

Reference Type

Technical Report

Title

NTP technical report on toxicity studies of ethylene glycol ethers: 2-Methoxyethanol, 2-ethoxyethanol, 2-butoxyethanol (CAS Nos 109-86-4, 110-80-5, 111-76-2) administered in drinking water to F344/N rats and B6C3F1 mice

Author(s)

Dieter, MP

Year

1993

Publisher

National Toxicology Program

Location

Research Triangle Park, NC

Report Number

NIH Publication 93-3349

URL

https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB94118106
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Abstract

Glycol alkyl ethers represent a class of high-production-volume chemicals with widespread industrial applications as solvents and chemical intermediates. Comparative toxicity studies with three glycol ethers, 2-methoxyethanol, 2-ethoxyethanol, and 2-butoxyethanol, were conducted in F344/N rats and B6C3F1 mice in both 2-week and 13-week drinking water studies. Toxicologic endpoints evaluated in animals included histopathology, hematology, clinical chemistry, urinalysis, and reproductive system parameters. Genetic toxicity was also evaluated for each glycol ether in several in vitro and in vivo assays.

Keywords

Rats Mice Organ weight Body weight Pathology Histology Neoplasms Mutagenicity tests; Ethylene glycols Toxicity Drinking water; 2-methoxyethanol 2-ethoxyethanol 2-butoxyethanol CAS 109-86-4 CAS 110-80-5 CAS 111-76-2