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Citation
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HERO ID
29823
Reference Type
Journal Article
Title
Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats
Author(s)
Pott, F; Ziem, U; Reiffer, FJ; Huth, F; Ernst, H; Mohr, U
Year
1987
Is Peer Reviewed?
Yes
Journal
Experimental and Toxicologic Pathology
ISSN:
0940-2993
EISSN:
1618-1433
Publisher
GUSTAV FISCHER VERLAG JENA
Location
JENA
Volume
32
Issue
3
Page Numbers
129-152
Language
English
PMID
3436395
DOI
10.1016/S0232-1513(87)80044-0
Web of Science Id
WOS:A1987K797400001
URL
https://linkinghub.elsevier.com/retrieve/pii/S0232151387800440
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Abstract
About 50 dusts were examined on their carcinogenicity in rats mainly after intraperitoneal injection and some after intratracheal instillation. In the i.p. test, very low doses between 0.05 and 0.5 mg asbestos led to tumour incidences of about 20 to 80%. Polyvinyl-pyridine-N-oxide prolonged the tumour latency after injection of actinolite. 60 mg attapulgite from three sources with short fibre lengths were not shown to be carcinogenic but an attapulgite sample with longer fibres had a moderate effect. Relatively thick rock and ceramic fibres (median greater than 1 micron) induced tumours, but slag and wollastonite fibres did not, probably because of their better solubility. Intratracheal instillations of glass microfibres (20 X 0.5 mg) led to lung tumours in 5 of 34 rats (0 in control). The carcinogenic potency of an inorganic fibre depends on its size and persistency, and possibly also on other properties, especially on the surface. Nickel powder, nickel oxide, nickel subsulfide and cadmium sulfide were all found to be carcinogenic in the two tests. Cadmium chloride and cadmium oxide could only be administered in very low doses because of their high acute toxicity. A high amount of magnetite (15 X 15 mg i.tr.) led to an unexpected lung tumour incidence of 69%. The i.p. test in rats proved to be very sensitive for detecting the carcinogenic potency of non-acute toxic natural and man-made mineral dusts as well as metal compounds. This means that, if a high dose of one of these dusts does not induce tumours in this test, no suspicion of carcinogenic potency can be substantiated.
Keywords
Carcinogens; Asbestos; 1332-21-4; Index Medicus; Asbestos -- adverse effects; Animals; Mutagenicity Tests; Rats, Inbred Strains; Metals -- adverse effects; Dust -- adverse effects
Tags
IRIS
•
Libby Amphibole Asbestos (Draft, 2011)
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
On topic - additional tags for titles/abstracts
Animal hazard ID
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
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