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Citation
Tags
HERO ID
29386
Reference Type
Book/Book Chapter
Title
Effect of carcinogens on the lung of guinea pigs
Author(s)
Hoch-Ligeti, C; Argus, MF
Year
1970
Publisher
United States Atomic Energy Comission, Division of Technical Information
Location
Oak Ridge, TN
Book Title
Morphology of Experimental Respiratory Carcinogenesis: Proceedings of a Biology Division, Oak Ridge National Laboratory, Conference held in Gatlinburg, Tennessee, May 13-16, 1970
Volume
21
Page Numbers
267-279
URL
https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=CONF700501
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Abstract
Spontaneous tumors in the lung of guinea pigs occur rarely. On intravenous injection of methylcholanthrene or dibenzanthracene, pulmonary tumors were induced in the guinea pig by Heston and Deringer. On oral adminsitration of the systemic carcinogens diethylnitrosamine and dioxane, tumors and tumor-like hyperplasias were induced in the lung of guinea ipigs in our laboratories. On intraperitoneal injection of the aglucone of cycasine, methylazoxymethanol, a tumor in the lung and malignant tumors in the nasal cavity of guinea pigs were induced by Spatz. In the lung of guinea pigs, tumors and tumor-like hyperplasias are multiple and are located peripherally, intrabronchially, and peribronchially. The lesions are peripheral papillary adenomas, intrabronchial respiratory or transitional cell papillomas, and peribronchial adenomatous hyperplasias. The resemblance of these lesions in the lung of guinea pigs to the pulmonary adenomatosis of mice and to the jagziekte of sheep is discussed.
Editor(s)
P Nettlesheim; MG Hanna Jr; JW Deatherage Jr
Tags
IRIS
•
1,4-Dioxane - with inhalation update
Final (2013)
External Review Draft (2011)
OPPT REs
•
OPPT_1,4-Dioxane_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
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