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Citation
Tags
HERO ID
224436
Reference Type
Journal Article
Subtype
Review
Title
A review of mechanisms of acrylamide carcinogenicity
Author(s)
Besaratinia, A; Pfeifer, GP
Year
2007
Is Peer Reviewed?
Yes
Journal
Carcinogenesis
ISSN:
0143-3334
EISSN:
1460-2180
Volume
28
Issue
3
Page Numbers
519-528
Language
English
PMID
17234719
DOI
10.1093/carcin/bgm006
Web of Science Id
WOS:000245351100002
Abstract
The fact that acrylamide, a proven rodent carcinogen, is present in significant quantities (up to several mg/kg of foodstuff) in a wide range of commonly consumed human foods is alarming. Attempts to determine a possible involvement of dietary acrylamide in human cancers have not been conclusive, however. To resolve the carcinogenicity of acrylamide to humans, the as yet unknown mechanism of action of acrylamide needs to be unraveled. The present review is a synopsis of research on the known and hypothetical modes of action of acrylamide of relevance for carcinogenesis. Both genotoxic and non-genotoxic modes of action of acrylamide are discussed with special emphasis on DNA-adduct targeted mutagenesis. Mechanistic data are presented from various experimental systems including in vitro experiments and in vivo rodent and human studies with special focus on mouse models. Updated human exposure data, estimates of daily intake of dietary acrylamide in different populations, and the corresponding cancer risk assessments are provided. The significant gaps in knowledge, which currently preclude a more definitive evaluation of human cancer risk due to exposure to dietary acrylamide are highlighted. Future directions for research on acrylamide and cancer are outlined, and potential challenges are underscored.
Keywords
Acrylamide; cancer; diet; DNA adducts; glycidamide; hemoglobin; mutations
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