Health & Environmental Research Online (HERO)


Print Feedback Export to File
224346 
Journal Article 
Dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis induced in male mouse germ cells by glycidamide, a metabolite of acrylamide 
Generoso, WM; Sega, GA; Lockhart, AM; Hughes, LA; Cain, KT; Cacheiro, NL; Shelby, MD 
1996 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
371 
3-4 
175-183 
The hypothesis that acrylamide induces dominant lethal mutations and heritable translocations in male mice, not through direct adduction, but by conversion to the reactive epoxide, glycidamide, was investigated. Three studies, namely, induction of dominant lethal mutations, heritable translocations, and unscheduled DNA synthesis in spermatids, which were conducted earlier in this laboratory for acrylamide, were also performed for glycidamide to determine its mutagenic properties and to compare responses. Results of these studies are consistent with the proposal that in vivo conversion to glycidamide is responsible for the mutagenicity of acrylamide in male mice.