Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
202896
Reference Type
Journal Article
Title
Carcinogenic effects of acrylamide in SENCAR and A/J mice
Author(s)
Bull, RJ; Robinson, M; Laurie, RD; Stoner, GD; Greisiger, E; Meier, JR; Stober, J
Year
1984
Is Peer Reviewed?
Yes
Journal
Cancer Research
ISSN:
0008-5472
EISSN:
1538-7445
Volume
44
Issue
1
Page Numbers
107-111
Language
English
PMID
6360343
URL
http://cancerres.aacrjournals.org/cgi/content/abstract/44/1/107
Exit
Abstract
Acrylamide structurally resembles vinyl carbamate, a proposed proximate carcinogenic form of ethyl carbamate. To test the hypothesis that acrylamide should possess carcinogenic properties, it was tested in the Salmonella-microsome assay for point mutation, as a skin tumor initiator in the Sencar mouse, and for its ability to induce lung adenomas in the A/J mouse. Acrylamide was found to be without activity as a mutagen in Salmonella strains TA 1535, TA 1537, TA 98, and TA 100 both in the presence and absence of rat liver microsomes using both the plate and liquid suspension assays. However, acrylamide was found to approximate ethyl carbamate in potency as a tumor initiator in the skin of the female Sencar mice. As with ethyl carbamate, acrylamide was more potent by systemic routes of administration relative to topical application. Acrylamide was also found to induce lung adenomas in male and female A/J mice using both the p.o. and i.p. routes of administration. Acrylamide was approximately one-seventh as potent as ethyl carbamate in the induction of lung adenomas. These data confirm the hypothesis that acrylamide possesses carcinogenic properties similar to ethyl carbamate.
Keywords
Acrylamide; Acrylamides/administration & dosage/*toxicity; Adenoma/chemically induced; Administration, Oral; Administration, Topical; Animals; *Carcinogens; Female; Injections, Intraperitoneal; Lung Neoplasms/*chemically induced; Mice; Mice, Inbred A; Mice, Inbred Strains; Mutagenicity Tests; Mutagens; Salmonella typhimurium/drug effects; Skin Neoplasms/*chemically induced; 0 (Acrylamides); 0 (Carcinogens); 0 (Mutagens); 79-06-1 (Acrylamide)
Tags
•
Harmful Algal Blooms- Health Effects
April 2021 Literature Search
PubMed
Scopus
Saxitoxins
PubMed
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity