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193312 
Journal Article 
Epidemiologic study of workers exposed to titanium dioxide 
Chen, JL; Fayerweather, WE 
1988 
Yes 
Journal of Occupational Medicine
ISSN: 0096-1736
EISSN: 2332-3795 
NIOSH/00185201 
30 
12 
937-942 
English 
3230444 
WOS:A1988R426500005 
The objective of this study was to determine whether workers exposed to titanium dioxide (TiO2) had significantly higher risks of lung cancer, chronic respiratory disease, pleural thickening/plaques, or pulmonary fibrosis than referent groups. A total of 1,576 employees exposed to TiO2 were observed from 1956 through 1985 for cancer and chronic respiratory disease incidence, and from 1935 through 1983 for mortality. A cross-sectional sample of 398 employees was evaluated for chest roentgenogram abnormalities. Cohort analyses suggested that the risks of developing lung cancer and other fatal respiratory diseases were no higher for TiO2-exposed employees than for the referent groups. Nested case-control analyses found no statistically significant associations between TiO2 exposure and risk of lung cancer, chronic respiratory disease, and chest roentgenogram abnormalities. No cases of pulmonary fibrosis were observed among TiO2-exposed employees. 
DCN-173942; Pulmonary system disorders; Epidemiology; Lung cancer; Lung fibrosis; Occupational exposure; Cancer rates; Demographic characteristics