Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
190109
Reference Type
Journal Article
Title
Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice
Author(s)
Yokota, S; Seki, T; Naito, Y; Tachibana, S; Hirabayashi, N; Nakasaka, T; Ohara, N; Kobayashi, H
Year
2008
Is Peer Reviewed?
1
Journal
Journal of Toxicological Sciences
ISSN:
0388-1350
EISSN:
1880-3989
Volume
33
Issue
5
Page Numbers
609-620
Language
English
PMID
19043282
Web of Science Id
WOS:000261624400010
Abstract
The influences of inhaling particulate air-pollutants on hematopoiesis and myocardial oxidative stress were investigated in mice by intratracheal instillation (IT) of diesel exhaust particles (DEP), its dichloromethane soluble-component (DMSC) or residual particle-component (RPC). After IT, time courses of cytokine levels in bronchial alveolar lavage fluid (BALF), peripheral blood cell count, myocardial myeloperoxidase (MPO) activity and myocardial chemokine levels were observed for 24 hr. RPC caused sustained blood neutrophilia while that caused by DEP and DMSC was transient. RPC also caused sustained elevations of granulocyte colony-stimulating factor (G-CSF) and interleukin (IL)-6 levels in BALF. Furthermore, IL-1beta level in BALF in the RPC group was significantly elevated at 24 hr after IT. Significant positive correlations were observed between blood neutrophil count and IL-6/G-CSF levels in BALF. MPO activity in the myocardium was increased by RPC at 12 and 24 hr after IT while the activities in the kidney and the liver were not affected. Significant correlation was also observed between myocardial MPO activity and blood neutrophil count at 12 hr after IT, for all three substances. From these results, it was concluded that particle component of DEP may enhance myocardial oxidative stress via blood neutrophilia and the elevation of cytokine levels in BALF.
Keywords
Air pollutant; Diesel exhaust particles; Neutrophilia; Oxidative stress; Myocardial myeloperoxidase
Tags
•
ISA-PM (2009 Final Project Page)
2009 Final
OPPT REs
•
OPPT_Methylene Chloride_F. Human Health
Total – title/abstract screening
Off topic
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity