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180280 
Journal Article 
On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies 
Lekki, J; Stachura, Z; Dabros, W; Stachura, J; Menzel, F; Reinert, T; Butz, T; Pallon, J; Gontier, E; Ynsa, MD; Moretto, P; Kertesz, Z; Szikszai, Z; Kiss, AZ 
2007 
1 
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
ISSN: 0168-583X 
260 
1 
174-177 
WOS:000248264900034 
We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle
size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 lm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands. 
titanium dioxide; nanoparticles; skin penetration; ion microprobe; autoradiography