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157928 
Journal Article 
Zinc and titanium oxides: promising UV-absorbers but what influence do they have on the intact skin? 
Lansdown, AB; Taylor, A 
1997 
Yes 
International Journal of Cosmetic Science
ISSN: 0142-5463
EISSN: 1468-2494 
IPA/98/1155175 
19 
REF 10 
167-72 
English 
18507634 
IPA COPYRIGHT: ASHP The percutaneous absorption and potential skin irritating effects of suspensions of 20% microfine or ACS grade zinc oxide and suspensions of 20% titanium dioxide (titanium oxide), each of which were prepared in water, castor oil, or polyethylene glycol, were studied in New Zealand rabbits; a single application of each suspension was left in place on the rabbits for a 4 h period or 3 applications of each suspension given every 24 h were left in place for 2 h periods. No irritation of rabbit skin was observed after the application of suspensions of zinc oxide or titanium dioxide. The results indicated that percutaneous absorption of zinc oxide and titanium dioxide occurred. The absorption was influenced by the type of vehicle used in the suspensions. 
Zinc oxide; absorption; percutaneous; Titanium dioxide; Water; titanium; Castor oil; Propylene glycol; Sunscreen agents; percutaneous absorption; zinc oxide(Sunscreen agents; titanium dioxide(Sunscreen agents; Topical preparations; zinc oxide(Topical preparations; titanium dioxide(Topical preparations; Suspensions; Formulations; Dosage forms; Particle size; Toxicity; Dosage schedules; Vehicles; titanium; Titanium oxide