Health & Environmental Research Online (HERO)


Print Feedback Export to File
157927 
Journal Article 
The photogenotoxicity of titanium dioxide particles 
Nakagawa, Y; Wakuri, S; Sakamoto, K; Tanaka, N 
1997 
1 
Mutation Research: Genetic Toxicology and Environmental Mutagenesis
ISSN: 1383-5718
EISSN: 1879-3592 
EMIC/105734 
394 
1-3 
125-132 
English 
9434851 
WOS:000071034400015 
We employed a series of in vitro genotoxicity assays--a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells--to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic. 
Titanium dioxide; Photogenotoxicity; Chromosome aberration; Single cell gel assay