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HERO ID
157547
Reference Type
Journal Article
Title
Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells
Author(s)
Kiss, B; Bíró, T; Czifra, G; Tóth, BI; Kertész, Z; Szikszai, Z; Kiss, AZ; Juhász, I; Zouboulis, CC; Hunyadi, J
Year
2008
Is Peer Reviewed?
1
Journal
Experimental Dermatology
ISSN:
0906-6705
EISSN:
1600-0625
Volume
17
Issue
8
Page Numbers
659-67
Language
English
PMID
18312389
DOI
10.1111/j.1600-0625.2007.00683.x
Web of Science Id
WOS:000257715300005
Abstract
Titanium dioxide (TiO2) nanoparticles are ubiquitously used materials in everyday life (e.g. paints,household products and plastic goods). However, despite the wide array of common applications, their pathogenetic role was also suggested under certain conditions (e.g. pulmonary neoplasias and lung fibrosis). From a dermatological point of view, it is also of great importance that TiO2 also serves as a physical photoprotective agent in sunscreens and is widely used in various cosmetic products. However, the effect of TiO2 on human cutaneous functions is still unknown. Therefore, in the current study, we investigated the in vivo penetration of TiO2 via human skin transplanted to immunodeficient mice and,furthermore, we measured the in vitro effects of nanoparticles on various functional properties of numerous epidermal and dermal cells in culture. Hereby, using various nuclear microscopy methods, we provide the first evidence that TiO2nanoparticles in vivo do not penetrate through the intact epidermal barrier. However, we also report that TiO2, when exposed directly to cell cultures in vitro, exerts significant and cell-type dependent effects on such cellular functions as viability, proliferation, apoptosis and differentiation. Therefore, our novel findings will hopefully inspire one to systemically explore in future, clinically oriented trials whether there is indeed a risk from micronized TiO2-containing products on skin with an impaired stratum corneum barrier function.
Keywords
Apoptosis; Differentiation; Epidermal penetration; Micronized titanium dioxide; Proliferation; Skin barrier
Tags
•
Nanoscale Carbon
All References Cited
Peer Reviewed Draft
Exposure, Uptake, and Dose
Priority Area: Ch. 4 and Appendix E
Final Case Study
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