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Citation
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HERO ID
157508
Reference Type
Journal Article
Title
A biocompatible medium for nanoparticle dispersion
Author(s)
Porter, D; Sriram, K; Wolfarth, M; Jefferson, A; Schwegler-Berry, D; Andrew, ME; Castranova, V
Year
2008
Is Peer Reviewed?
1
Journal
Nanotoxicology
ISSN:
1743-5390
EISSN:
1743-5404
Volume
2
Issue
3
Page Numbers
144-154
DOI
10.1080/17435390802318349
Web of Science Id
WOS:000260297200005
Abstract
Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant.
However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory
variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a
‘lung fluid mimic’. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined
that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also
determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se
did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall,
these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies.
Keywords
Nanoparticles; nanotoxicology; nanotubes
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