Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

157457

Reference Type

Journal Article

Title

Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model

Author(s)

Lee, HA; Leavens, TL; Mason, SE; Monteiro-Riviere, NA; Riviere, JE

Year

2009

Is Peer Reviewed?

Journal

Nano Letters
ISSN: 1530-6984
EISSN: 1530-6992

Volume

Issue

Page Numbers

794-799

Language

English

PMID

19128005

DOI

10.1021/nl803481q

Abstract

A physiologically based pharmacokinetic model with partition coefficients estimated from quantum dot (QD) 705 biodistribution was compared with the biodistribution of other QDs in mice and rats to determine the model's predictive ability across QD types, species, and exposure routes. The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo.

Keywords

Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution